This inventor holds 5 USPTO granted patents. Top assignees: University of Vermont, Haematologic Technologies, Inc.. Active years: 1995-2013.
Location History:
- Burlington, VT (US) (1995)
- South Burlington, VT (US) (2003 - 2013)
Company Filing History:
Years Active: 1995-2013
Title: The Innovations of Saulius Butenas
Introduction
Saulius Butenas is a notable inventor based in South Burlington, Vermont, with a significant contribution to the field of biomedical research. He holds five patents that focus on the detection of critical factors related to blood coagulation and cardiovascular health. His work has implications for understanding and diagnosing various medical conditions.
Latest Patents
Among his latest patents, Butenas has developed methods for the detection of Factor XIa and Tissue Factor (TF). This invention provides compositions and methods for detecting FXIa or TF activity in a sample using an antibody-based clotting time prolongation assay. Additionally, it includes methods for detection using a fluorogenic substrate. The research highlights a correlation between elevated levels of FXIa and/or TF with several health issues, including inflammation, acute coronary syndrome, myocardial infarction, coronary artery disease, heart failure, aortic stenosis, stroke, and transient ischemic attack. Notably, the frequency of FXIa and TF activity was found to be substantially lower in individuals with stable coronary artery disease and no history of myocardial infarction, while no FXIa or TF activity was observed in healthy individuals. Another patent focuses on assays for detecting and quantifying tissue factor and factor VIIa in biological systems, utilizing aminonapthalene-based fluorogenic substrates.
Career Highlights
Saulius Butenas has had a distinguished career, working with reputable organizations such as Haematologic Technologies, Inc. and the University of Vermont. His experience in these institutions has allowed him to advance his research and contribute to significant innovations in the field of hematology.
Collaborations
Throughout his career, Butenas has collaborated with esteemed colleagues, including Kenneth G Mann and Jeffrey H Lawson. These partnerships have further enriched his research and development efforts.
Conclusion
Saulius Butenas is a prominent inventor whose work in the detection of blood coagulation factors has the potential to impact medical diagnostics significantly. His contributions continue to advance the understanding of cardiovascular health and related conditions.