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For the Inventor, By the Inventor

Kingston, Canada

Saul Wolfe

USPTO Granted Patents = 15

Average Co-Inventor Count = 1.4

ph-index = 6

Forward Citations = 96(Granted Patents)


Company Filing History:

goldMedal15 out of 414 
 
Queen's University at Kingston
 patents

Years Active: 1976-1989

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15 patents (USPTO):Explore Patents
1. 4847200 - Biosynthesis of unnatural cephalosporins (1989-07-11),
2. 4693977 - Enzyme immobilization for producing cephalosporin antibiotics (1987-09-15),
3. 4579818 - Biosynthesis of unnatural cephalosporins (1986-04-01),
4. 4536476 - Stable epimerase reagent, cyclase reagent and ring expansion reagent for (1985-08-20),
5. 4514333 - Intermediates for process for 1-oxacephem derivatives (1985-04-30),
6. 4510246 - Isolation of cyclase, epimerase and a ring expansion enzyme for (1985-04-09),
7. 4391975 - Process for 1-oxacephem derivatives (1983-07-05),
8. 4208325 - Preparation of 1-oxapenicillins and 4-acyloxy azetidinone intermediates (1980-06-17),
9. 4200571 - 4-Chloroazetidinone (1980-04-29),
10. 4071512 - Preparation of 1-oxapenicillins and intermediates therefor (1978-01-31),
11. 4018782 - 2,2-Dimethyl-3R-carboxy-6S- (1977-04-19),
12. 4013653 - 1-Oxacephems (1977-03-22),
13. 3985764 - Production of fused oxazoline azetidinones (1976-10-12),
14. 3950352 - 2,2-Dimethyl-3R-carboxy-6S-phenyl(or (1976-04-13),
15. 3948927 - 2,2-Dimethyl-3R-carboxy-6S-amino-1-oxa-4-aza-5R-bicyclo-[3,2,0]heptan-7-o (1976-04-06),

Title: The Innovative Contributions of Saul Wolfe

Introduction

Saul Wolfe is a distinguished inventor based in Kingston, CA. He has made significant contributions to the field of biochemistry, particularly in the development of antibiotics. With a total of 15 patents to his name, Wolfe's work has had a profound impact on medical science.

Latest Patents

Wolfe's latest patents include groundbreaking processes for the biosynthesis of unnatural cephalosporins. This innovative method involves producing unnatural penicillins and cephalosporin derivatives through the reaction of peptide analogs of ACV with various enzymes isolated from prokaryotic organisms such as S. clavuligerus. The outcome of this process is influenced by the presence of co-factors like ferrous ion, α-ketoglutarate, and ascorbate. Another notable patent focuses on enzyme immobilization for producing cephalosporin antibiotics. In this process, enzymes extracted from β-lactam producing microorganisms are immobilized on a support to create desacetoxycephalosporin and its analogs.

Career Highlights

Wolfe is currently affiliated with Queen's University at Kingston, where he continues to advance his research in antibiotic development. His innovative approaches have garnered attention in the scientific community, leading to numerous patents that reflect his expertise and dedication.

Collaborations

Wolfe has collaborated with notable colleagues, including Donald Westlake and Susan E. Jensen. These partnerships have further enriched his research and contributed to the success of his innovative projects.

Conclusion

Saul Wolfe's contributions to the field of biochemistry and antibiotic development are noteworthy. His innovative patents and collaborations highlight his commitment to advancing medical science.

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