Location History:
- Krishnalok Lucknow, IN (2014)
- Lucknow, IN (2012 - 2017)
Company Filing History:
Years Active: 2012-2017
Title: Innovator Satya P Bajpai: Pioneering Advances in Synthetic Nucleosides and RNA Synthesis
Introduction
Satya P Bajpai is a distinguished inventor based in Lucknow, India, recognized for his significant contributions to the realm of synthetic nucleosides and RNA synthesis. With a total of four patents, Bajpai has made strides in developing innovative solutions that address DNA damage and enhance the quality of synthetic RNA.
Latest Patents
Among his latest patents, one noteworthy invention is focused on "Nucleosides and oligonucleotides for studies on reversal of cytotoxic and mutagenic damage of DNA and as diagnostic tools." This invention introduces n-alkylated synthetic nucleosides characterized by high regiospecific purity, serving as crucial tools in researching the reversal of DNA damage and presenting a valuable resource for diagnostic applications.
Another significant advancement pertains to "RNA synthesis—phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3'-end." This invention encompasses novel phosphoramidites, specifically A-n-bz, C-n-bz, C-n-ac, G-n-ac, and U, noted for their HPLC purity exceeding 98% and P NMR purity surpassing 99%. This novel process unveils a reverse 5'→3' directed synthesis methodology for RNA oligomers, showcasing high-quality RNA synthesis with impressive coupling efficiency nearing 99%.
Career Highlights
Satya P Bajpai currently works at Chemgenes Corporation, where he continues to innovate and lead in the field of nucleic acid research. His work at Chemgenes has garnered attention for its potential applications in both diagnostic and therapeutic realms.
Collaborations
At Chemgenes Corporation, Bajpai collaborates with esteemed colleagues such as Suresh C Srivastava and Divya Pandey. Together, they form a dynamic team, pushing the boundaries of research and development in synthetic biology and nucleic acid chemistry.
Conclusion
With a focus on enhancing our understanding of DNA functionality and RNA synthesis, Satya P Bajpai stands at the forefront of innovation in synthetic nucleosides. His patented inventions are indicative of a greater trend in biotechnological advancements, promising substantial implications for medical diagnostics and therapeutic developments in the years to come.
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