Company Filing History:
Years Active: 1997-2000
Title: Innovations of Satish K Bhatnagar
Introduction
Satish K Bhatnagar is a notable inventor based in Gaithersburg, MD (US). He has made significant contributions to the field of nucleic acid amplification, holding a total of five patents. His work focuses on enhancing the efficiency and accuracy of nucleic acid detection methods.
Latest Patents
One of his latest patents involves the development of labeled nucleic acid amplification oligonucleotides with molecular energy. This invention provides oligonucleotides that can function as linear or hairpin primers or blocking oligonucleotides. The oligonucleotides are labeled with donor and/or acceptor moieties of molecular energy transfer pairs. These moieties can be fluorophores, allowing the fluorescent energy emitted by the donor to be absorbed by the acceptor. The acceptor may either be a fluorophore that fluoresces at a different wavelength than the donor or a quencher. The configuration of these oligonucleotides ensures that both donor and acceptor moieties are incorporated into the amplification product. Additionally, the invention includes methods and kits for directly detecting amplification products using these nucleic acid amplification primers. When labeled linear primers are utilized, treatment with exonuclease or specific temperature conditions eliminates the need for separating unincorporated primers. This 'closed-tube' format significantly reduces the risk of carryover contamination with amplification products, facilitates high throughput of samples, and can be fully automated.
Career Highlights
Throughout his career, Satish has worked with several prominent companies, including Oncor, Inc. and Intergen Company. His experience in these organizations has contributed to his expertise in the field of molecular biology and nucleic acid technologies.
Collaborations
Satish has collaborated with notable colleagues such as Irina A Nazarenko and Emily S Winn-Deen. These partnerships have further enriched his research and development efforts in nucleic acid amplification technologies.
Conclusion
Satish K Bhatnagar's innovative work in nucleic acid amplification has led to significant advancements in the field. His contributions continue to impact the efficiency and accuracy of molecular detection methods.