Company Filing History:
Years Active: 2025
Title: Innovations of Sarah Rinde Oikemus
Introduction
Sarah Rinde Oikemus is an accomplished inventor based in Holden, MA (US). She has made significant contributions to the field of genetic research, particularly in the area of gene editing. Her work focuses on developing innovative solutions for genetic diseases through advanced techniques.
Latest Patents
Oikemus holds a patent titled "Allele-specific inactivation of mutant HTT via gene editing at coding region single nucleotide polymorphisms." This invention contemplates allele-specific gene editing by targeting a heterozygous single nucleotide polymorphism (SNP) in a protein coding sequence associated with a genetic disease. The data presented demonstrates that this gene editing approach creates a nonsense mutation, leading to a marked and selective reduction of mutant protein without affecting wild type protein expression. The expression of a single CRISPR-Cas9 nuclease in neurons has shown a high frequency of mutations in the targeted HD allele, including both small insertion/deletion mutations and viral vector insertions. This innovative method provides a feasible approach to inactivate autosomal dominant mutations that cause genetic diseases.
Career Highlights
Oikemus is affiliated with the University of Massachusetts, where she continues her research and development in genetic engineering. Her work has garnered attention for its potential impact on treating genetic disorders.
Collaborations
She has collaborated with notable colleagues, including Michael Harry Brodsky and Neil Aronin, contributing to advancements in her field.
Conclusion
Sarah Rinde Oikemus is a pioneering inventor whose work in gene editing holds promise for addressing genetic diseases. Her innovative approaches and collaborations highlight her commitment to advancing scientific knowledge and improving health outcomes.