Location History:
- Memphis, TN (US) (2001)
- New Haven, CT (US) (2001 - 2004)
Company Filing History:
Years Active: 2001-2004
Title: Sara M Bodner: Innovator in Gene Regulation
Introduction
Sara M Bodner is a prominent inventor based in New Haven, CT (US). She has made significant contributions to the field of gene regulation, holding a total of 3 patents. Her work focuses on the interactions between D-type cyclins and transcription factors, which play a crucial role in cellular processes.
Latest Patents
One of her latest patents is titled "Cyclin D binding factor, and uses thereof." This invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor known as DMP1. DMP1 specifically interacts with cyclin D2, providing evidence that D-type cyclins can regulate gene expression in an RB-independent manner. The invention includes amino acid sequences coding for DMP1, as well as DNA and RNA nucleotide sequences that encode these amino acid sequences. Additionally, the patent reveals the use of DMP1 as a transcription factor due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. When DMP1 is transfected into mammalian cells, it activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.
Career Highlights
Sara M Bodner is affiliated with St. Jude Children's Research Hospital, where she continues her research and innovation in gene regulation. Her work has been instrumental in advancing our understanding of cellular mechanisms and their implications in health and disease.
Collaborations
Some of her notable coworkers include Charles J Sherr and Hiroshi Hirai, who have collaborated with her on various research projects.
Conclusion
Sara M Bodner is a distinguished inventor whose work in gene regulation has led to important advancements in the field. Her patents reflect her innovative approach to understanding complex biological processes.