Santhosh Kumar Thatikonda

Title: Innovations of Santhosh Kumar Thatikonda

Introduction

Santhosh Kumar Thatikonda is an accomplished inventor based in Woburn, MA, with a focus on advancements in nucleic acid chemistry. He holds three patents that showcase his innovative contributions to the field. His work emphasizes the development of novel compounds and methodologies that enhance the synthesis and functionality of oligonucleotides.

Latest Patents

One of his latest patents is titled "Dithiolane functionalized nucleoside amidites and supports for stronger immobilization of bio-molecules on solid surfaces." This invention describes novel 1,2-dithiolane functionalized nucleoside phosphoramidites and corresponding solid supports. The nucleosides developed in this patent carry a primary hydroxyl for DMTr function, allowing for efficient chain elongation under standard DNA and RNA synthesis conditions. These derivatives are particularly useful for introducing reactive thiol groups at the ends of oligonucleotides on solid supports such as gold and silver.

Another significant patent is "Dithiolane based thiol modifier for labeling and stronger immobilization of bio-molecules on solid surfaces." This invention addresses the need for stable thiol modified oligonucleotides that can withstand higher temperatures and salt concentrations. The cyclic disulfide thiol modifier introduced in this patent allows for the incorporation of multiple thiol groups, enhancing the stability and functionality of oligonucleotides. The successful synthesis of 20-mer and 21-mer oligonucleotides containing dithiolane derivatives demonstrates the effectiveness of these innovations.

Career Highlights

Santhosh Kumar Thatikonda has worked with notable companies, including Chemgenes Corporation, where he has contributed to various projects in nucleic acid chemistry. His expertise and innovative approach have made a significant impact in the field.

Collaborations

Throughout his career, he has collaborated with esteemed colleagues such as Suresh C Srivastava and Sant K Srivastav, further enhancing the scope and reach of his research.

Conclusion

Santhosh Kumar Thatikonda's contributions to nucleic acid chemistry through his patents and collaborations highlight his role as a leading inventor in the field. His innovative approaches continue to advance the understanding and application of oligonucleotides in various scientific domains.