Sanjay Khare

Title: **Innovator Spotlight: Sanjay Khare**

Introduction

Sanjay Khare is a distinguished inventor based in Newbury Park, California, with an impressive portfolio of 13 patents. His innovative work primarily revolves around the field of biochemistry, particularly the development of activatable binding polypeptides that have the potential to revolutionize therapeutic applications.

Latest Patents

Among his latest patents, Khare has introduced groundbreaking concepts such as activatable anti-VEGF scFv. This disclosure reveals activatable binding polypeptides (ABPs) with a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The ABPs are designed to adopt an 'activatable' conformation where at least one TBM becomes less accessible to the target when uncleaved, with subsequent accessibility upon cleavage in the presence of a specific cleaving agent. This innovative approach enhances the effectiveness of therapeutic treatments targeting key proteins like VEGF, CTLA-4, and VCAM, along with libraries of candidate ABPs, methods for screening, and manufacturing techniques for these advanced molecules.

Career Highlights

Sanjay Khare has made significant contributions to the field of biotechnology through his roles at leading institutions. He has worked with notable organizations, including the University of California and CytomX Therapeutics, Inc. His work has been instrumental in advancing research and developing new therapeutic strategies through his patented innovations.

Collaborations

Throughout his career, Khare has collaborated with esteemed colleagues like Patrick Sean Daugherty and Jerry Thomas. These collaborations reflect his commitment to advancing science and technology through teamwork and shared expertise, leading to innovative discoveries that have the potential to make a significant impact in the field.

Conclusion

Sanjay Khare's continued dedication to research and innovation in developing activatable binding polypeptides underscores the importance of inventors in driving progress in biotechnology. With 13 patents to his name, his work holds promise for advancements in therapies that target critical biological processes, demonstrating the pivotal role of inventors like Khare in shaping the future of science and healthcare.