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Years Active: 2025
Title: Innovations of Sanford L Boye
Introduction
Sanford L Boye is a prominent inventor based in Gainesville, FL (US). He has made significant contributions to the field of biomedical research, particularly in the treatment of genetic disorders affecting the eye and ear. With a total of 2 patents, his work has the potential to improve the quality of life for individuals suffering from Usher syndrome and related conditions.
Latest Patents
One of his latest patents is focused on Dual AAV-MYO7A vectors with improved safety for the treatment of Usher syndrome IB (USH1B). This patent discloses compositions and methods for treating diseases of the mammalian eye, specifically complications of the retina associated with USH1B. Additionally, it addresses complications of ear hair cells associated with the same syndrome. The invention provides improved AAV-based, dual vector systems that facilitate the expression of full-length proteins whose coding sequences exceed the packaging capacity of an individual AAV vector. The modified hybrid dual vector systems shift the coding sequence for the MY07A tail domain to eliminate the production of truncated MY07A protein. Furthermore, it describes improved, codon-modified hybrid and overlap vector systems that remove putative stop codons and residual sequences in non-coding regions. Another significant patent involves methods and compositions for expressing Otoferlin, utilizing adeno-associated viral (AAV) particles, which may be useful for treating Deafness, Autosomal Recessive 9 (DFNB9).
Career Highlights
Sanford L Boye has worked with esteemed institutions such as the University of Florida Research Foundation and the University of California. His research has been pivotal in advancing gene therapy techniques and understanding the genetic basis of hearing and vision disorders.
Collaborations
Throughout his career, Boye has collaborated with notable colleagues, including Frank Dyka and William W Hauswirth. These partnerships have contributed to the success and impact of his research endeavors.
Conclusion
Sanford L Boye's innovative work in the field of gene therapy exemplifies the potential of scientific research to address complex genetic disorders. His contributions continue to pave the way for advancements in treatment options for affected individuals.