Company Filing History:
Years Active: 2002-2004
Title: **The Innovative Contributions of Sandra Silver in Immunology**
Introduction
Sandra Silver is an accomplished inventor based in Boston, MA, known for her groundbreaking work in immunology. With a total of two patents to her name, her contributions have significant implications in the field of immune response modulation.
Latest Patents
Sandra's latest patents include the development of CTLA4-immunoglobulin fusion proteins that possess modified effector functions. The innovations describe how these fusion proteins are designed to contain two essential components: a first peptide dedicated to CTLA4 activity and a second peptide that incorporates an immunoglobulin constant region. This region has been altered to diminish at least one constant region-mediated biological effector function compared to the traditional CTLA4-IgG1 fusion protein. The nucleic acids encoded by these proteins can be integrated into various expression vectors, facilitating the synthesis of the corresponding proteins in multiple hosts, especially eukaryotic cells. The potential applications of these CTLA4-immunoglobulin fusion proteins include suppressing immune responses in subjects, particularly in scenarios such as transplantation rejection, graft-versus-host disease, and various autoimmune disorders.
Career Highlights
Currently, Sandra Silver is employed at Repligen Corporation, where she continues to make impactful contributions to the field of immunology through her innovative ideas and research. Her work has been crucial in advancing therapeutic strategies to manage immune-related conditions.
Collaborations
Throughout her career, Sandra has worked alongside talented colleagues, including Gary S. Gray and Jerry Carson. These collaborations have enriched her research and led to enhanced developments in her area of expertise, allowing for broader implications in immunotherapy.
Conclusion
Sandra Silver's innovative work in developing CTLA4-immunoglobulin fusion proteins highlights her significant role as an inventor in immunology. Her contributions are poised to advance treatment options for various immune-related issues, showcasing the importance of creativity and research in medical sciences.