Sandra Afione

Title: Sandra Afione: Innovator in Gene Therapy

Introduction

Sandra Afione is a prominent inventor based in Bethesda, MD (US). She has made significant contributions to the field of gene therapy, particularly through her work with adeno-associated virus vectors. With a total of 5 patents to her name, her innovations have the potential to transform medical treatments for genetic disorders.

Latest Patents

One of her latest patents involves a modified adeno-associated virus vector capable of expression from a novel transcription promoter. This invention describes constructions of recombinant DNA comprising modified AAV DNA sequences that function as eukaryotic expression vectors. The research demonstrates that expression of a test reporter gene can be achieved in mammalian cells using this vector. Furthermore, it shows that this combination can introduce and express a human gene, correcting genetic defects caused by malfunctioning endogenous genes. The vector can also express a modified version of the human gene, which consists of a fusion of part of the gene and a synthetic sequence contained in the vector.

Career Highlights

Sandra Afione works for the United States of America as represented by the Department of Health. Her career is marked by her dedication to advancing gene therapy technologies and improving patient outcomes through innovative research.

Collaborations

Some of her notable coworkers include Barrie J Carter and Terence Flotte. Their collaborative efforts have contributed to the success of her research and the development of groundbreaking therapies.

Conclusion

Sandra Afione is a trailblazer in the field of gene therapy, with her innovative work paving the way for new treatments for genetic disorders. Her contributions are invaluable to the scientific community and hold promise for future medical advancements.