This inventor holds 6 USPTO granted patents and 2 published patent applications and 1 EPO patent. Top assignees: University of Florida Research Foundation Inc., University of Pennsylvania, Cornell University. Active years: 2012-2025.
Company Filing History:
6 out of 3,050 
6 out of 2,655 
2 out of 2,949 
Years Active: 2012-2025
Title: Innovator Samuel Jacobson: Pioneering Treatments for Retinitis Pigmentosa
Introduction
Samuel Jacobson, a distinguished inventor based in Penn Valley, Pennsylvania, has made significant contributions to the field of genetic therapies, particularly in the treatment of retinitis pigmentosa. With a total of six patents to his name, Jacobson's innovations focus on cutting-edge methods to address genetic disorders affecting vision.
Latest Patents
Among his latest patents, two stand out for their innovative approach to treating dominant retinitis pigmentosa. The first patent details compositions and methods for treatment, offering a novel way to deliver interfering RNA that targets the expression of both alleles of the RHO gene in affected individuals. The patent also includes provisions for delivering a replacement RHO coding sequence, designed to be resilient against the interfering RNA.
The second patent builds on this concept, focusing on AAV vectors for the same treatment. This approach also utilizes interfering nucleic acids to reduce the expression of the mutant RHO allele associated with retinitis pigmentosa, while simultaneously providing a resistant replacement gene.
Career Highlights
Jacobson has collaborated with notable research institutions, including the University of Pennsylvania and the University of Florida Research Foundation, Incorporated. His academic and research endeavors have established him as a prominent figure in the field of genetic therapy.
Collaborations
Throughout his career, Jacobson has worked closely with esteemed colleagues such as William W. Hauswirth and Gustavo D. Aguirre. Their collaborative efforts have undoubtedly advanced the research and development of innovative solutions for hereditary retinal diseases.
Conclusion
Samuel Jacobson's pioneering work in the treatment of retinitis pigmentosa exemplifies the crucial role of inventors in addressing complex medical challenges. With his groundbreaking patents and collaborative spirit, Jacobson continues to inspire future innovations in genetic therapy and visual health.