Samuel B Leslie

Title: Innovations by Samuel B Leslie

Introduction

Samuel B Leslie is an accomplished inventor based in Alexandria, VA, with a focus on advancements in the field of erythrocyte stabilization. He holds two patents that contribute significantly to the medical and biological sciences.

Latest Patents

Leslie's latest patents revolve around the innovative methods for storing tissues and cells, particularly erythrocytes. One of his notable inventions involves a method for stabilizing erythrocytes using a reversible stabilizing agent. This method includes several steps: stabilizing the cells, loading them with a cryoprotectant, and storing them in various states such as liquid, frozen, or dry. Additionally, prior to use, the stabilization reaction can be reversed. The process also anticipates the reoxygenation of erythrocytes and the washing out of reagents before in vivo application. Another aspect of his invention is the reversible crosslinking of proteins in erythrocytes, which enhances their shape stability and post-transfusion survival.

Career Highlights

Samuel B Leslie works for the USA as represented by the Secretary of the Navy. His contributions to the field of erythrocyte research have been recognized for their potential to improve medical practices related to blood storage and transfusion.

Collaborations

Leslie has collaborated with notable coworkers, including Irina B Bakaltcheva and Alan S Rudolph, who have contributed to his research endeavors.

Conclusion

Samuel B Leslie's innovative work in erythrocyte stabilization showcases his commitment to advancing medical technology. His patents reflect a significant contribution to the field, promising improvements in blood storage and transfusion practices.