Samuel A F Williams

Title: Samuel A F Williams: Innovator in HIV Research

Introduction

Samuel A F Williams is a notable inventor based in San Mateo, CA. He has made significant contributions to the field of HIV research, particularly in developing methods to combat latent HIV reservoirs. His work is crucial in the ongoing fight against HIV/AIDS.

Latest Patents

Samuel A F Williams holds a patent for "Methods and compositions for the synergistic activation of latent HIV." This invention provides methods and compositions useful for eliminating latent HIV reservoirs that persist despite Highly Active Antiretroviral Therapy (HAART). The methods induce the replication of HIV in latently infected T cells while preventing the spread of newly produced virions to uninfected cells by administering HAART simultaneously. The compositions include an activator of latent HIV expression, such as prostratin, and an inhibitor of histone deacetylase, such as TSA. A surprising finding of this invention is that the histone deacetylase inhibitor synergizes the effect of prostratin, allowing for a lower, non-toxic dose of prostratin to be administered to patients.

Career Highlights

Samuel A F Williams is affiliated with the J. David Gladstone Institutes, where he conducts his research. His work has been instrumental in advancing our understanding of HIV latency and potential therapeutic strategies.

Collaborations

One of his notable collaborators is Warner C Greene, with whom he has worked on various research projects related to HIV.

Conclusion

Samuel A F Williams is a key figure in HIV research, with a focus on innovative methods to activate latent HIV. His contributions are vital in the quest for effective treatments against HIV/AIDS.