Samia Mankarious

Title: Samia Mankarious: Innovator in Factor IX Formulations

Introduction

Samia Mankarious is a notable inventor based in the United States. She has made significant contributions to the field of biotherapeutics, particularly in the formulation of Factor IX. Her work focuses on enhancing the stability and storage conditions of this important protein.

Latest Patents

Samia Mankarious holds a patent for "Stabilized Factor IX Formulations Containing Trehalose." This patent discloses methods for preparing lyophilized preparations of Factor IX that preserve more than 90% of its calcium binding property. The formulations containing trehalose demonstrate superior stability after 12 weeks of storage at 25°C/60% relative humidity and 40°C/75% relative humidity compared to those without trehalose. The inclusion of trehalose allows for potential temperature excursions and long-term room temperature storage of Factor IX lyophilized products.

Career Highlights

Samia Mankarious is currently employed at Aptevo Biotherapeutics LLC, where she continues to innovate in the field of biotherapeutics. Her research has led to formulations that maintain comparable stability over extended periods, even under challenging storage conditions.

Collaborations

Samia collaborates with Michael J Griffith, contributing to the advancement of their shared goals in biotherapeutic research.

Conclusion

Samia Mankarious is a pioneering inventor whose work on Factor IX formulations has the potential to significantly impact the field of biotherapeutics. Her innovative approaches to stability and storage conditions are paving the way for future advancements in this area.