Company Filing History:
Years Active: 2014-2016
Title: Innovations of Inventor Sami Mahrus
Introduction
Sami Mahrus is a notable inventor based in San Francisco, CA. He has made significant contributions to the field of biomarker discovery and proteomic profiling. With a total of two patents to his name, Mahrus is recognized for his innovative approaches to understanding apoptosis and protein labeling.
Latest Patents
Mahrus's latest patents include the discovery of candidate biomarkers of in vivo apoptosis by global profiling of caspase cleavage sites. This invention relates to the identification of novel biomarkers that are useful for detecting and quantifying apoptosis in biological samples. The invention also provides synthetic peptides and proteins that correspond to neo-epitopes created by proteolytic processing of these cleavage sites. These synthetic peptides can serve as standards for identifying and quantifying biomarkers using mass spectrometry. Additionally, the synthetic proteins can be utilized to generate antibodies and other binding reagents specific for these biomarkers. The patent also outlines methods for detecting apoptosis and diagnosing diseases characterized by apoptosis, along with compositions and kits for performing these methods.
Another significant patent by Mahrus is focused on the specific N-terminal labeling of peptides and proteins in complex mixtures. This invention provides general methods for the selective labeling of proteins on their N-termini with synthetic peptides. These methods can be applied to the global proteomic profiling of complex mixtures of proteins and polypeptides, enhancing the understanding of protein interactions and functions.
Career Highlights
Sami Mahrus is affiliated with the University of California, where he continues to advance research in his field. His work has garnered attention for its potential applications in medical diagnostics and therapeutic development.
Collaborations
Mahrus has collaborated with James A Wells, a fellow researcher, to further explore the implications of his inventions in the scientific community.
Conclusion
Sami Mahrus is a distinguished inventor whose work in biomarker discovery and proteomic profiling has the potential to impact various fields, particularly in understanding and diagnosing diseases. His innovative patents reflect a commitment to advancing scientific knowledge and improving healthcare outcomes.