Company Filing History:
Years Active: 2022
Title: Saki Shimizu: Innovator in Gene Modification
Introduction
Saki Shimizu is a notable inventor based in Berkeley, California. She has made significant contributions to the field of genetic engineering, particularly in the development of innovative methods for gene modification.
Latest Patents
Saki Shimizu holds a patent for a potent short hairpin RNA (shRNA734) directed to human Hypoxanthine Guanine Phosphoribosyltransferase (HPRT). This invention improves the rate of gene-modified stem cell engraftment through a conditioning and in vivo selection strategy. The shRNA734 confers resistance to a clinically available guanine analog antimetabolite, 6TG, facilitating the efficient positive selection of gene-modified stem cells. The applications of this technology include methods for knocking down HPRT in a cell, conferring resistance to a guanine analog antimetabolite, producing selectable genetically modified cells, and treating subjects infected with HIV.
Career Highlights
Saki Shimizu is affiliated with the University of California, where she continues her research and development in genetic engineering. Her work has garnered attention for its potential applications in medical therapies and genetic research.
Collaborations
Saki collaborates with Dong Sung An, who is also involved in the field of genetic research. Their partnership enhances the scope and impact of their work in gene modification.
Conclusion
Saki Shimizu's innovative contributions to genetic engineering, particularly through her patent on shRNA734, highlight her role as a leading inventor in this critical area of research. Her work promises to advance the field and improve therapeutic strategies for various diseases.