Sachet Ashok Shukla

Title: Sachet Ashok Shukla: Innovator in Genetic Research

Introduction

Sachet Ashok Shukla is a prominent inventor based in Newton, MA (US). She has made significant contributions to the field of genetic research, particularly in the areas of polymorphic gene typing and somatic change detection. With a total of 3 patents, her work is paving the way for advancements in immunogenic compositions and cancer treatment.

Latest Patents

One of her latest patents focuses on polymorphic gene typing and somatic change detection using sequencing data. This system and method determine the exact pair of alleles corresponding to polymorphic genes from sequencing data. It utilizes reads from a sequencing dataset that map to target polymorphic genes in a canonical reference genome sequence. The method extracts reads mapping within a defined threshold of the target gene sequence locations and matches them against a probe reference set. This innovative approach allows for the inference of an individual's ethnicity based on available sequencing data, which can then be used to assign prior probabilities to allele variants.

Another significant patent involves identifying somatic changes in polymorphic loci using whole exome sequencing (WES) data. This method determines the exact pair of alleles corresponding to polymorphic genes using normal or germline samples from individuals. It also retrieves tumor or diseased samples to generate corresponding WES data. The alignment of germline or normal reads to inferred allele sequences, along with tumor reads, enhances the precision and sensitivity of somatic change detection algorithms.

Her work also includes a pharmaceutical composition comprising a plurality of neoantigenic peptides capable of binding to HLA proteins in subjects. This composition targets tumor-specific mutations present in a significant percentage of cancer patients, aiming to elicit an immune response against tumors.

Career Highlights

Sachet has worked with notable organizations such as the Broad Institute, Inc. and Dana-Farber Cancer Institute. Her experience in these prestigious institutions has allowed her to collaborate with leading experts in the field of cancer research.

Collaborations

Some of her notable coworkers include Edward F. Fritsch and Nir Hacohen, who have contributed to her research endeavors.

Conclusion

Sachet Ashok Shukla's innovative work in genetic research and her contributions to the understanding of polymorphic genes and cancer treatment are commendable. Her patents reflect her dedication to advancing medical science and improving patient outcomes.