Ruth Winter

Title: Ruth Winter: Innovating in Antibody Therapeutics

Introduction

Ruth Winter, an accomplished inventor based in Oakland, CA, has made significant strides in the field of biopharmaceuticals. With two notable patents to her name, she is paving the way for advancements in the treatment of bleeding disorders. Her innovative research is particularly impactful in the development of therapies for conditions such as hemophilia.

Latest Patents

Ruth Winter's latest patents include cutting-edge technologies that harness the power of antibodies. The first patent, titled "Thrombin/plasmin-regulated antibodies that bind TFPI," introduces protease-regulated antibodies that specifically target tissue factor pathway inhibitor (TFPI). These antibodies are designed for therapeutic applications in treating bleeding disorders.

The second patent, "Anti-TFPI antibody variants with differential binding across pH range for improved pharmacokinetics," presents a groundbreaking approach to enhancing antibody efficacy. This innovation features antibodies that inhibit the anti-coagulant function of TFPI, exhibiting a lower affinity at pH 6.0 compared to pH 7.4. This strategic modification allows for improved pharmacokinetics by reducing target-mediated clearance, thereby enhancing the antibodies’ circulating half-life. Specific histidine residue substitutions are disclosed, demonstrating a refined understanding of antibody binding dynamics.

Career Highlights

Ruth Winter is currently associated with Bayer Healthcare LLC, where she applies her expertise to the development of novel therapeutic solutions. Her work not only contributes to the body of knowledge in biomedical research but also has the potential to make significant impacts on patient care.

Collaborations

Throughout her career, Ruth has collaborated with esteemed colleagues such as Zhuozhi Wang and John R. Murphy. These partnerships have fostered an environment of innovation and creativity, leading to advancements that push the boundaries of existing medical technologies.

Conclusion

Ruth Winter stands out as a prominent figure in the realm of biopharmaceutical innovation. Her contributions through her patents on antibody therapies signify a crucial step forward in treating complex bleeding disorders. With her ongoing research and collaborations, she continues to make valuable contributions to the scientific community, ultimately benefiting patients who rely on advanced medical solutions.