Location History:
- Mumbai, IN (2013 - 2014)
- Seattle, WA (US) (2017 - 2022)
Company Filing History:
Years Active: 2013-2024
Title: Innovations by Rupali Patwardhan
Introduction
Rupali Patwardhan is a prominent inventor based in Seattle, WA (US). She has made significant contributions to the field of DNA sequencing, holding a total of 8 patents. Her work focuses on improving methods for preparing DNA sequencing libraries, which are crucial for various genomic analyses.
Latest Patents
One of her latest patents is titled "Sequence tag directed subassembly of short sequencing reads into long sequencing reads." This invention relates to a method for preparing a DNA sequencing library that enhances the proximity of fragmentation breakpoints to the non-degenerate sequence tag. The method involves circularizing a target fragment library with adaptor molecules to produce a population of first circularized double-stranded DNA molecules. This innovation is particularly useful for sequencing platforms that perform optimally with shorter template molecules, typically less than about 500 base pairs in length.
Another notable patent is "Error detection in sequence tag directed sequencing reads." This invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences. This is essential for genome assembly, full-length cDNA sequencing, metagenomics, and analyzing repetitive sequences of assembled genomes.
Career Highlights
Rupali Patwardhan has established herself as a leading figure in her field through her innovative research and development efforts. Her work has significantly advanced the capabilities of DNA sequencing technologies, making them more efficient and reliable.
Collaborations
Rupali has collaborated with esteemed colleagues such as Jay Ashok Shendure and Joseph Brian Hiatt. These collaborations have further enriched her research and contributed to the success of her inventions.
Conclusion
Rupali Patwardhan's contributions to DNA sequencing technology exemplify her innovative spirit and dedication to advancing scientific knowledge. Her patents reflect her commitment to improving genomic analysis methods, making her a valuable asset to the University of Washington and the scientific community at large.