Ruizhi Guo

Title: Ruizhi Guo and His Work on Macrocyclic Compound Crystals.

Introduction

Ruizhi Guo is an inventor based in Guangzhou, China, and is associated with Hitgen, Inc. His patent work concerns pharmaceutical synthesis, including the crystal form of a macrocyclic compound and its preparation and use.

Latest Patents

Guo is named on one patent: “Crystal Form of Macrocyclic Compound, and Preparation Method Therefor and Use Thereof.” The invention describes a crystal form of a macrocyclic compound identified as (6R,16R)-9-fluoro-16-methyl-13-oxa-2,17,21,25-tetraazapentane [16.6.2.000]dihexadecane-1(25),7,9,11,18(26),19,21,23-octane-19-carbonitrile.

The patent identifies characteristic X-ray diffraction peaks at 2θ values of 9.49±0.2, 10.60±0.2, 11.54±0.2, 14.10±0.2, 17.09±0.2, 19.15±0.2, 20.30±0.2, 22.85±0.2, 23.89±0.2, and 27.74±0.2. The described crystal form is reported to be non-hygroscopic and to have good stability and pharmacokinetic properties. The patent also addresses methods for preparing the crystal form and its potential use.

Career Highlights

Guo’s listed patent activity focuses on a pharmaceutical compound’s solid-state form and related preparation methods. The patent describes properties relevant to the compound’s stability and pharmacokinetic performance.

Collaborations

Guo is associated with Hitgen, Inc. His listed coworkers include Haihong Ye and Fei Qin.

Conclusion

Ruizhi Guo’s patent work, associated with Hitgen, Inc., centers on a macrocyclic compound crystal form, its preparation, and its potential pharmaceutical use.