This inventor holds 2 USPTO granted patents. Top assignee: University of Kentucky Research Foundation. Active years: 2012-2014.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2012-2014
Title: Innovations of Royce Mohan in Chemical Genetic Probes
Introduction
Royce Mohan is an accomplished inventor based in Lexington, KY (US). He has made significant contributions to the field of chemical genetics, particularly through his innovative work on withanolides. With a total of 2 patents, his research focuses on identifying binding targets and developing methods for drug screening.
Latest Patents
Mohan's latest patents include groundbreaking work on withanolide chemical genetic probes. These probes are designed to identify the in vivo binding target of withaferin A, specifically the intermediate filament type III protein vimentin. His research has led to the development of a small molecule screening method that screens drug candidates targeting intermediate filament type III proteins. This method involves introducing a tagged linker covalently bonded to the withanolide molecule to form a withanolide probe. The affinity-labeled withanolide can also be utilized to find intermediate filament-associated proteins through chemical proteomics. Furthermore, these probes can monitor the expression of vimentin in tumor samples or other diseased tissues. Mohan's work also explores the use of withaferin analogs as potential treatments for various vimentin-associated disorders, including cancers and chronic inflammation.
Career Highlights
Royce Mohan is affiliated with the University of Kentucky Research Foundation, where he continues to advance his research in chemical genetics. His innovative approaches have the potential to revolutionize the treatment of fibrotic diseases by screening for drugs effective in treating these conditions.
Collaborations
Mohan collaborates with notable colleagues, including Paola Bargagna-Mohan and Kyung Bo Kim, to further enhance the impact of his research.
Conclusion
Royce Mohan's contributions to the field of chemical genetics through his innovative patents and research at the University of Kentucky Research Foundation highlight his role as a leading inventor. His work not only advances scientific understanding but also holds promise for developing new therapeutic strategies.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile