Roy Musil

Title: Roy Musil: Innovator in Heparinase Research

Introduction

Roy Musil is a notable inventor based in Carlsbad, California. He has made significant contributions to the field of biochemistry, particularly in the study of heparinase enzymes. With a total of 2 patents to his name, Musil's work has implications for medical and pharmaceutical applications.

Latest Patents

Musil's latest patents focus on nucleic acid sequences and expression systems for heparinase II. The first patent describes the isolation and sequence of genes from Flavobacterium heparinum that encode heparin and heparan sulfate degrading enzymes, specifically heparinase II and heparinase III. It outlines a method for expressing these enzymes using a modified ribosome binding region derived from a promoter from glycosaminoglycan lyase genes of F. heparinum. Additionally, the patent details a multi-step protein purification method that includes cell disruption, cation exchange chromatography, affinity chromatography, and hydroxylapatite chromatography. It also discusses antibodies against a post-translational modification moiety common to Flavobacterium heparinum proteins and methods to obtain antibodies specific to these moieties and the amino acid sequences of heparinases I, II, and III.

Career Highlights

Musil has been instrumental in advancing the understanding of heparinase enzymes. His work at Ibex Technologies Ltd. has positioned him as a key figure in biotechnological research. His innovative approaches have paved the way for new methodologies in enzyme expression and purification.

Collaborations

Throughout his career, Musil has collaborated with notable colleagues, including Hongsheng Su and Francoise Blain. These partnerships have enhanced the scope and impact of his research.

Conclusion

Roy Musil's contributions to the field of heparinase research exemplify the importance of innovation in biotechnology. His patents and collaborative efforts continue to influence advancements in medical science.