Company Filing History:
Years Active: 1999-2000
Title: Roy Guillermo: Innovator in Cell Selection Technologies
Introduction
Roy Guillermo is a notable inventor based in Carson, California. He has made significant contributions to the field of cell selection technologies, holding 2 patents that focus on innovative methods for the release of target cells from heterogeneous cell suspensions.
Latest Patents
Guillermo's latest patents include a method for positive and positive/negative cell selection mediated by peptide release. This invention provides a non-enzymatic approach for the release of cells that have been selected through antibody-mediated binding to solid supports. The method involves forming a complex within the cell suspension, which includes a solid support linked to a primary monoclonal antibody bound to a cell surface antigen on the target cells. After separating the complex from the cell suspension, a specific peptide is introduced, which binds to the primary antibody, displacing it from the cell surface antigen and thereby releasing the target cell. This invention is particularly useful for the positive selection of CD34+ hematopoietic stem cells while purging undesired tumor cells or lymphocytes from the selected population. The purified CD34+ cell composition can then be reinfused into cancer patients after high-dose therapy to help reconstitute their immune systems.
Career Highlights
Roy Guillermo has established himself as a key figure in the biotechnology sector, particularly through his work at Nexell Therapeutics Inc. His innovative approaches have the potential to significantly impact cancer treatment and regenerative medicine.
Collaborations
Guillermo collaborates with talented professionals in his field, including Janet Tseng-Law and Joan A Kobori. Their combined expertise contributes to the advancement of cell selection technologies.
Conclusion
Roy Guillermo's work in cell selection technologies exemplifies the innovative spirit of modern biotechnology. His patents not only enhance our understanding of cell manipulation but also pave the way for improved therapeutic strategies in cancer treatment.