Roxana Jalili

Title: **Roxana Jalili: Innovator Behind a Breakthrough in Proximity Ligation Assays**

Introduction

Roxana Jalili is a notable inventor based in Palo Alto, California, known for her pioneering work in the field of molecular biology. With a keen focus on enhancing the precision of diagnostic methods, she has made significant contributions through her innovative inventions.

Latest Patents

Roxana Jalili holds a patent for a highly specific circular proximity ligation assay. This invention employs proximity-probes as bridges to connect two free oligonucleotides via a dual ligation event, resulting in the formation of a circle. The circles formed are then quantified using techniques such as qPCR. Notably, the inclusion of an extra oligonucleotide is designed to enhance specificity by reducing the likelihood of random background ligation events. Furthermore, the circular structure allows for the removal of uncircularized DNA via simple exonuclease treatment, streamlining workflow by eliminating the need for preamplification prior to qPCR.

Career Highlights

Roxana is associated with Stanford University, where she continues to push the boundaries of scientific research. Her work not only exemplifies innovation in laboratory procedures but also adds significant value to diagnostic methodologies in various applications.

Collaborations

Throughout her career, Roxana Jalili has collaborated with esteemed colleagues, including Henrik H J Persson and Joseph L Horecka. These partnerships have been instrumental in advancing her research and enhancing the impact of her invention in the scientific community.

Conclusion

Roxana Jalili stands as a distinguished inventor whose contributions are paving the way for more specific and efficient diagnostic tools. Her patent on the circular proximity ligation assay signifies her commitment to innovation and improvement in molecular biology techniques.