Ross S Basch

Title: Ross S Basch: Innovator in Transcriptional Regulation

Introduction

Ross S Basch is a notable inventor based in New York, NY (US). He has made significant contributions to the field of transcriptional regulation, with a focus on the modulation of nuclear hormone receptor activity. With a total of 2 patents, his work has implications in both human and mouse genetics.

Latest Patents

One of his latest patents involves the C21 polypeptide, which modulates the stability of transcriptional regulatory complexes. This gene, designated C21, encodes a family of proteins that play a crucial role in transcriptional regulation. Two isoforms, α and β, produced by alternative splicing, have been identified in humans. A transgenic model created by Basch shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development, suggesting that members of this family are involved in regulating stem cell differentiation. Additionally, over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with co-repressors of nuclear hormone receptors, which are critical for transcription. Another patent of his is for N,N'-bis(4-azidobenzoyl)cystine, which is useful as photoaffinity labels.

Career Highlights

Ross S Basch is affiliated with New York University, where he continues to advance research in his field. His innovative work has garnered attention and respect within the scientific community.

Collaborations

Some of his notable coworkers include Michiel E Ultee and Xin-Min Zhang, who have contributed to his research endeavors.

Conclusion

Ross S Basch is a prominent inventor whose work in transcriptional regulation has the potential to impact various fields, including genetics and cellular biology. His contributions through patents reflect his commitment to advancing scientific knowledge and innovation.