The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2006
Filed:
Nov. 15, 2001
Ross S. Basch, New York, NY (US);
Xin-min Zhang, Bronx, NY (US);
Ross S. Basch, New York, NY (US);
Xin-Min Zhang, Bronx, NY (US);
New York University, New York, NY (US);
Abstract
A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors.