This inventor holds 2 USPTO granted patents. Top assignee: University of California. Active years: 2000-2003.
Company Filing History:
Years Active: 2000-2003
Title: The Innovative Contributions of Rosalie M Uht
Introduction
Rosalie M Uht is a prominent inventor based in San Francisco, CA. She has made significant contributions to the field of biotechnology, particularly in the area of gene expression and hormone receptor research. With a total of 2 patents, her work has advanced the understanding of how drugs can interact with nuclear receptors.
Latest Patents
One of her latest patents is titled "Expression of human estrogen receptors in transgenic mice." This invention relates to improved compositions and methods for assaying the efficacy of novel drugs functioning either as agonists or antagonists at nuclear receptors. The invention provides transgenic non-human animals that comprise a human steroid hormone receptor gene operably linked to a promoter, which directs expression of the steroid hormone receptor gene in an epithelial cell of the non-human animals.
Another significant patent is "Methods to screen for transcription factor-coactivator interactions." This invention provides methods for modulating gene expression at the transcriptional level. The methods involve tethering a transcriptional coactivator to a DNA binding domain that is specific for a target nucleic acid sequence and contacting the coactivator with a transcription factor. The transcription factor triggers or represses transcription mediated by the coactivator. Additionally, methods for identifying compounds that can modulate gene expression are also provided.
Career Highlights
Rosalie M Uht is affiliated with the University of California, where she conducts her research and development. Her work has been instrumental in advancing the understanding of gene regulation and hormone receptor functionality.
Collaborations
She has collaborated with notable colleagues such as Peter J Kushner and Paul Webb, contributing to a rich environment of innovation and discovery.
Conclusion
Rosalie M Uht's contributions to biotechnology through her patents and research have significantly impacted the field. Her innovative work continues to pave the way for advancements in drug efficacy and gene expression modulation.