Company Filing History:
2 out of 5 
2 out of 274 
1 out of 1 Years Active: 2006
Title: The Innovations of Ronit Rafaeloff-Phail
Introduction
Ronit Rafaeloff-Phail is a notable inventor based in Indianapolis, IN (US). He has made significant contributions to the field of biotechnology, particularly in the area of pancreatic islet neogenesis. With a total of 3 patents, his work has garnered attention for its potential applications in medical science.
Latest Patents
Rafaeloff-Phail's latest patents include groundbreaking research on the high level of expression of INGAP in bacterial and eukaryotic cells. His findings indicate that the removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts had only yielded low amounts of INGAP, likely due to the toxic nature of the signal sequence to the cells. Another significant patent involves the INGAP protein's role in pancreatic islet neogenesis. His research demonstrated that cellophane wrapping of hamster pancreas induces the proliferation of duct epithelial cells, leading to endocrine cell differentiation and islet neogenesis. Through the mRNA differential display technique, he identified a cDNA clone expressed in cellophane-wrapped pancreata, which led to the discovery of a previously uncharacterized gene named INGAP.
Career Highlights
Throughout his career, Ronit Rafaeloff-Phail has worked with esteemed institutions such as Eastern Virginia Medical School and McGill University. His research has contributed to advancements in understanding pancreatic functions and potential treatments for diabetes.
Collaborations
Rafaeloff-Phail has collaborated with notable colleagues, including Aaron I Vinik and Gary L Pittenger. Their combined expertise has furthered the impact of his research in the scientific community.
Conclusion
Ronit Rafaeloff-Phail's innovative work in biotechnology, particularly regarding INGAP and pancreatic islet neogenesis, showcases his dedication to advancing medical science. His contributions continue to inspire future research and development in the field.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.