Company Filing History:
6 out of 1,217 
2 out of 3,539 
Years Active: 1994-2022
Title: The Innovations of Ronald N Germain
Introduction
Ronald N Germain is a prominent inventor based in Potomac, MD (US). He holds a total of 8 patents that reflect his significant contributions to the field of biomedical research. His work primarily focuses on methods and compositions that enhance the understanding of tissue characteristics and T cell responses.
Latest Patents
One of Germain's latest patents is titled "Method and composition for optical clearing of tissues." This invention discloses compositions, methods, and kits for clearing tissue while preserving cellular morphology, reporter fluorescence, and epitope labeling. These advancements allow for quantitative phenotypic analysis of intact organs. The compositions include a compound of formula R—C(X)—NRR, where R is alkyl, haloalkyl, hydroxyalkyl, amino, or alkylamino, and X is O or S. The patent also outlines methods for visualizing tissue characteristics, which involve fixing, staining, and imaging the tissue using a microscope or tissue scanning device.
Another significant patent by Germain is "T cell receptor ligands and methods of using same." This invention concerns TCR ligands with immunomodulatory properties. It includes methods for identifying such ligands and utilizing them to modulate T cell effector responses, which is crucial for advancing immunotherapy techniques.
Career Highlights
Germain has made substantial contributions while working with the United States of America as represented by the Department of Health and the National Institutes of Health, a component of the US Department of Health & Human Services. His work has been instrumental in advancing the understanding of immune responses and tissue analysis.
Collaborations
Throughout his career, Germain has collaborated with notable colleagues, including Luigi Racioppi and Jay A Berzofsky. These collaborations have further enriched his research and innovations in the field.
Conclusion
Ronald N Germain's innovative work in tissue analysis and immunology has led to significant advancements in biomedical research. His patents reflect a commitment to enhancing our understanding of complex biological systems.