The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 1998
Filed:
Sep. 18, 1991
Applicant:
Inventors:
Jay A Berzofsky, Bethesda, MD (US);
Hidemi Takahashi, Tokyo, JP;
Ronald N Germain, Potomac, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
4241881 ; 4242081 ; 530326 ; 530327 ;
Abstract
The instant invention describes the synthesis of short peptides, corresponding to the amino acid residues of the V3 loop of the gpl6O envelope glycoprotein of HIV-1 numbered 315 to 329 by Ratner (Ratner, L. et al., Nature 313, 277 (1985)) in the strain IIIB, wherein the residue corresponding to number 325 in HIV-1 IIIB is substituted by the homologous residue from another clinical isolate or strain. The invention further describes the use of said peptides in pharmaceutical compositions and an immunization protocol which elicits cytotoxic T cells reactive to a broad range of isolates of HIV-1.