Company Filing History:
Years Active: 1998-2001
Title: The Innovations of Ronald J Green
Introduction
Ronald J Green is a notable inventor based in Toronto, Canada. He has made significant contributions to the field of genetics and molecular biology. With a total of 3 patents to his name, his work focuses on advancing methods for DNA sequence determination and mutation detection.
Latest Patents
One of Ronald J Green's latest patents is a method and system for DNA sequence determination and mutation detection. This innovative approach begins with obtaining at least one raw fragment pattern for an experimental sample. The raw fragment pattern represents the positions of a selected nucleic acid base within the polymer as a function of migration time or distance. The raw fragment pattern is then conditioned using conventional baseline correction and noise reduction techniques to yield a clean fragment pattern. Following this, the clean fragment pattern is evaluated to determine one or more normalization coefficients. These coefficients reflect the displacement, stretching or shrinking, and rate of stretching or shrinking of the clean fragment, which are necessary to achieve a high degree of correlation between the clean fragment pattern and a standard fragment pattern. The normalization coefficients are subsequently applied to produce a normalized fragment pattern, which is used for base-calling in a conventional manner. This method can be implemented in an apparatus comprising a computer processor programmed to determine normalization coefficients for an experimental fragment pattern.
Career Highlights
Ronald J Green is currently associated with Visible Genetics Inc., where he continues to innovate in the field of genetic research. His work has been instrumental in developing technologies that enhance the accuracy and efficiency of DNA sequencing.
Collaborations
Some of Ronald J Green's notable coworkers include John K Stevens and Vrijmoed Chi. Their collaborative efforts contribute to the advancement of genetic technologies and methodologies.
Conclusion
Ronald J Green's contributions to the field of genetics through his patents and work at Visible Genetics Inc. highlight his role as a significant innovator in DNA sequencing technologies. His advancements continue to impact the scientific community positively.