Ronald Greene

Title: The Innovations of Inventor Ronald Greene

Introduction

Ronald Greene is an accomplished inventor based in Durham, NC, known for his significant contributions to the field of biotechnology. With a remarkable portfolio that includes four patents, Greene has made strides in the development of novel proteins, particularly in relation to growth hormones and antibody fragments.

Latest Patents

One of Greene's notable patents is the "Enrichment method for variant proteins with altered binding properties." This innovative method facilitates the selection of novel proteins that exhibit altered binding properties for their respective receptor molecules. By fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13, Greene has been able to create a library of structurally related fusion proteins. These proteins are expressed in low quantities on the surface of phagemid particles. Through biological selection and screening processes, novel ligands are identified, paving the way for potential drug candidates. This patent includes detailed descriptions of preferred phagemid expression vectors and selected variants of human growth hormone.

Another significant contribution is the "Monovalent phage display," which shares a similar methodology for selecting proteins. This patent elaborates on the fusion of genes and formation of protein libraries, underscoring Greene’s innovative techniques that continue to shape the landscape of protein development.

Career Highlights

Ronald Greene currently works at Genentech, Inc., a leading biotechnology company renowned for its focus on pharmaceuticals and drug development. His work at Genentech has enabled him to collaborate with other talented individuals in the field, creating a strong impact on ongoing research and development projects.

Collaborations

Throughout his career, Greene has partnered with esteemed colleagues, including Steven H Bass and Henry Bernard Lowman. These collaborations leverage the diverse expertise of his coworkers, enhancing the scope and impact of Greene’s inventive work.

Conclusion

In summary, Ronald Greene's innovative approaches in biotechnology, particularly through his patents concerning protein variants, have made him an influential figure in the field. His contributions at Genentech, along with his collaborations with fellow inventors, continue to drive forward significant advancements in medical and pharmaceutical research. Greene’s work exemplifies the essence of innovation in addressing complex challenges in drug development.