Rommel A Mathias

Title: Rommel A Mathias: Innovator in Cellular Biochemistry

Introduction

Rommel A Mathias is a distinguished inventor based in Plainsboro, NJ (US). He has made significant contributions to the field of cellular biochemistry, particularly through his innovative research and patents. With a total of 2 patents, Mathias has focused on the mechanisms of cellular processes that are crucial for understanding metabolic regulation.

Latest Patents

Mathias's latest patents include groundbreaking work on Sirtuin 4 (SIRT4) lipoamidase activity and its applications. One of his notable patents provides a method for assaying pyruvate dehydrogenase complex (PDHC) activity in mammalian cells expressing human SIRT4. This method involves measuring the level of a dihydrolipoyllysine acetyltransferase (DLAT) lipoamide peptide with a specific amino acid sequence. His research demonstrates that SIRT4 functions as a cellular lipoamidase, negatively regulating PDHC activity through the hydrolysis of its lipoamide cofactors.

Career Highlights

Rommel A Mathias is affiliated with Princeton University, where he continues to advance his research in biochemistry. His work has implications for understanding metabolic diseases and developing therapeutic strategies. His innovative approaches have garnered attention in the scientific community, contributing to the advancement of knowledge in cellular metabolism.

Collaborations

Mathias has collaborated with notable colleagues, including Thomas E Shenk and Todd M Greco. These partnerships have enriched his research and expanded the impact of his findings in the field.

Conclusion

Rommel A Mathias is a prominent inventor whose work in cellular biochemistry has led to significant advancements in understanding metabolic regulation. His contributions through patents and research continue to influence the scientific community and pave the way for future innovations.