Company Filing History:
Years Active: 2001-2003
Title: Romas Gelezuinas: Innovator in Inflammatory Response Research
Introduction
Romas Gelezuinas is a prominent inventor based in San Francisco, CA. He has made significant contributions to the field of immunology, particularly in understanding and modulating inflammatory responses. With a total of 2 patents, his work has implications for therapeutic interventions in various inflammatory diseases.
Latest Patents
Gelezuinas's latest patents focus on inhibitors of the inflammatory response induced by TNFα and IL-1. These inventions provide a molecular basis for cytokine induction of NF-κB-dependent immune and inflammatory responses. They emphasize the role of both NIK-NIK and NIK-IKK protein-protein interactions. The patents detail methods for inhibiting NF-κB-dependent gene expression using mutant NIK proteins. One embodiment includes kinase-deficient NIK mutant proteins that inhibit the activation of IKK. Another embodiment features N-terminus NIK mutant proteins that bind IKK, thereby inhibiting the NIK/IKK interaction.
Career Highlights
Romas Gelezuinas is affiliated with the University of California, where he conducts his research. His work has garnered attention for its innovative approach to tackling complex immune responses. His research has the potential to lead to new therapeutic strategies for managing inflammatory conditions.
Collaborations
Gelezuinas has collaborated with notable researchers in his field, including Warner C Greene and Xin Lin. These collaborations have further enriched his research and contributed to advancements in understanding inflammatory mechanisms.
Conclusion
Romas Gelezuinas is a key figure in the field of immunology, with a focus on inflammatory responses. His patents and research efforts continue to pave the way for innovative treatments in this critical area of health.