Roman Sobotik

Title: The Innovations of Roman Sobotik

Introduction

Roman Sobotik is a notable inventor based in Opava, Czech Republic. He has made significant contributions to the field of chemistry, particularly in the development of processes for synthesizing important pharmaceutical compounds. His work is characterized by a focus on creating efficient methods for the preparation of key intermediates used in analgesic synthesis.

Latest Patents

Roman Sobotik holds a patent for a process titled "Process for the preparation of 3, 14.beta.-dihydroxy-17-normorphinan." This patent outlines a suitable economic process for synthesizing 3,14.beta.-dihydroxy-17-normorphinan, which is a crucial intermediate in the semisynthetic synthesis of Butorphanol, an effective analgesic derived from thebaine. The synthesis involves a two-step N-demethylation and concerted dephenoxylation of 4-phenoxy-14.beta.-hydroxy-3-methoxymorphinan, utilizing chloroformate in the first step and sodium action in liquid ammonia in the second step, followed by O-demethylation using a complex of aluminum chloride and dialkylsulfide.

Career Highlights

Roman Sobotik is associated with Galena AS, where he continues to innovate and contribute to the field of pharmaceutical chemistry. His expertise in synthesis processes has positioned him as a valuable asset in the development of new analgesic compounds.

Collaborations

Throughout his career, Roman has collaborated with notable colleagues, including Petr Bulej and Tomas Kolasin. These partnerships have fostered a collaborative environment that enhances the innovation process and leads to significant advancements in their field.

Conclusion

Roman Sobotik's contributions to the field of pharmaceutical chemistry, particularly through his patented processes, highlight his role as an influential inventor. His work not only advances the synthesis of important analgesics but also showcases the importance of innovation in the pharmaceutical industry.