Company Filing History:
Years Active: 2009-2016
Title: Romain N Zufferey: Innovator in Gene Therapy
Introduction
Romain N Zufferey is a prominent inventor based in Palo Alto, CA (US). He has made significant contributions to the field of gene therapy through his innovative work on lentiviral vectors. With a total of 3 patents, Zufferey is recognized for his advancements in creating safe and efficient systems for gene expression.
Latest Patents
Zufferey's latest patents focus on methods and compositions relating to improved lentiviral vector production systems. These inventions provide HIV-derived lentivectors that are multiply modified to enhance safety, efficiency, and potency for expressing transgenes in gene therapy. The lentiviral vectors include various combinations of an inactive central polypurine tract, a stuffer sequence that may encode drug susceptibility genes, and a mutated hairpin in the 5' leader sequence that significantly reduces replication. These elements are integrated with other features of lentiviral vectors, such as a self-inactivating configuration for biosafety and various promoters, including the EF1α promoter. Additionally, the vectors can incorporate transcription-enhancing elements like the woodchuck hepatitis virus post-transcriptional regulatory element. This innovative approach provides valuable tools for genetic treatments of inherited and acquired disorders, cancer therapies, and the study of fundamental cellular and genetic processes.
Career Highlights
Zufferey has established himself as a key figure in the field of gene therapy. His work has not only advanced scientific understanding but has also paved the way for practical applications in medical treatments. His dedication to research and development has made a significant impact on the industry.
Collaborations
Zufferey collaborates with Didier Trono, a fellow researcher, to further enhance the development of lentiviral vectors and their applications in gene therapy.
Conclusion
Romain N Zufferey is a notable inventor whose work in gene therapy has led to groundbreaking advancements in lentiviral vector technology. His contributions continue to influence the field and offer promising solutions for various genetic disorders.