Company Filing History:
Years Active: 1992-1995
Title: Rolf F Barth: Innovator in Boron Neutron Capture Therapy
Introduction
Rolf F Barth is a notable inventor based in Columbus, OH (US). He has made significant contributions to the field of boron neutron capture therapy through his innovative patents. With a total of 2 patents, Barth's work focuses on enhancing treatment methods for tumor cells.
Latest Patents
Barth's latest patents include "Carboranyl uridines and their use in boron neutron capture therapy." This invention relates to novel boron-containing nucleosides and amino acids that can utilize the enzymatic systems in tumor cells for incorporating boron-containing structures into nucleic acids and proteins. The subsequent use of boron neutron capture therapy provides a method for effectively treating tumor cells. Another significant patent is "2' and 3' Carboranyl uridines and their diethyl ether adducts." This patent discloses a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron-containing nucleoside compounds. These compounds demonstrate enhanced lipophilicity and hydrophilic properties, enabling solvation in aqueous media for incorporation in methods for boron neutron capture therapy in mammalian tumor cells.
Career Highlights
Rolf F Barth is affiliated with The Ohio State University, where he continues to contribute to research and innovation in his field. His work has the potential to significantly impact cancer treatment methodologies.
Collaborations
Barth has collaborated with notable individuals in his field, including Albert H Soloway and Abul K Anisuzzaman. These collaborations have furthered the development of his innovative ideas and patents.
Conclusion
Rolf F Barth is a distinguished inventor whose work in boron neutron capture therapy showcases his commitment to advancing medical treatments. His patents reflect a deep understanding of the complexities involved in cancer therapy, and his contributions are poised to make a lasting impact in the field.