Rohini Mitra

Title: Innovations of Rohini Mitra

Introduction

Rohini Mitra is a prominent inventor based in Bridgewater, NJ (US). She has made significant contributions to the field of biotechnology, particularly in the development of antibody formulations. With a total of five patents to her name, her work has advanced the understanding and application of high-concentration antibody therapies.

Latest Patents

One of Rohini Mitra's latest patents focuses on stable compositions of high-concentration allotype-selected antibodies for small-volume administration. This patent discloses methods, compositions, and uses of high-concentration antibody or immunoglobulin formulations for various administration routes, including subcutaneous, intramuscular, and transdermal. The formulations are designed for administration in volumes less than 3 ml, with a preference for volumes of less than 2 ml or even 1 ml. The formulation typically includes a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate 80, and mannitol at a pH of about 5.2. It is noted that the formulation can contain at least 100, 150, 200, 250 mg/ml, or even 300 mg/ml of antibody. The methods for preparing these high-concentration formulations involve ultrafiltration and diafiltration to concentrate the antibody and exchange the medium for the HCF buffer. Additionally, the patent discusses the use of non-G1m1 (nG1m1) allotype antibodies, such as G1m3 and/or nG1m1,2 antibodies, which exhibit decreased immunogenicity compared to G1m1 antibodies.

Career Highlights

Rohini Mitra has established herself as a key figure in her field through her innovative research and development efforts. She is currently employed at Immunomedics, Inc., where she continues to work on advancing antibody therapies.

Collaborations

Throughout her career, Rohini has collaborated with notable colleagues, including Li Zeng and Edmund A. Rossi. These collaborations have contributed to her success and the advancement of her research.

Conclusion

Rohini Mitra's contributions to the field of biotechnology, particularly in antibody formulation, have been significant. Her innovative patents and collaborations highlight her role as a leading inventor in her area of expertise.