Company Filing History:
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Years Active: 2018-2020
Title: Roger McLendon: Pioneering Researcher in Oligodendroglioma Genetics
Introduction
Roger McLendon, based in Durham, NC, is a distinguished inventor and researcher known for his significant contributions to the understanding of oligodendrogliomas, a serious form of brain tumor. With a total of two patents to his name, McLendon has been at the forefront of exploring the molecular genetic basis of brain tumors, specifically focusing on chromosomal abnormalities that threaten patient health.
Latest Patents
Roger McLendon’s latest patents relate to the identification of drive genes in oligodendrogliomas. His research highlights the complexity of these tumors, which are characterized by a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19. Through exomic sequencing of anaplastic oligodendrogliomas showing losses of chromosome 1p and 19q, McLendon discovered critical mutations in the CIC and FUBP1 genes. Notably, 58% of the identified mutations were predicted to result in protein truncations, underscoring the importance of these genes in the pathology of oligodendrocytes.
Career Highlights
Throughout his career, Roger McLendon has worked with prestigious institutions, including The Johns Hopkins University and Duke University. His research has paved the way for a deeper understanding of genetic alterations associated with oligodendrogliomas, contributing valuable insights into potential therapeutic targets.
Collaborations
McLendon's impactful work has been enhanced through collaborations with prominent colleagues such as Bert Vogelstein and Kenneth W. Kinzler. Together, they have collectively contributed to advancing the field of brain tumor genetics and enhancing the scientific community's knowledge regarding oligodendrogliomas.
Conclusion
Roger McLendon's innovative research and discoveries in the genetic basis of oligodendrogliomas have made significant strides in the field. His contributions not only add to the understanding of these tumors but also open new avenues for potential treatments, showcasing the critical role of research in combating cancer.
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