Location History:
- San Diego, CA (US) (1995 - 2000)
- Alameda, CA (US) (2000 - 2001)
- Dallas, TX (US) (2001)
Company Filing History:
Years Active: 1995-2001
Title: Innovations in Taxo-Diterpenoid Nanostructures by Rodney K Guy
Introduction
Rodney K Guy is an accomplished inventor based in San Diego, CA. He has made significant contributions to the field of nanotechnology, particularly in the development of taxo-diterpenoid nanostructures. With a total of 8 patents, his work has the potential to impact various applications in medicine and drug delivery.
Latest Patents
One of his latest patents focuses on self-assembled taxo-diterpenoid nanostructures. This invention involves onium salts of taxo-diterpenoid-C,,2-O-aza-arenes that form water-soluble self-assembling nanostructures above a critical aggregation concentration. The onium salt of aza-arene includes a delocalized charge, enhancing the solubility of derivatized taxo-diterpenoids in water and promoting the formation of structures such as helical fibular and spherical micellular structures. These onium salts are also utilized as water-soluble prodrugs, exemplified by taxol-2′-methylpyridinium tosylate (MPT), which exhibits elevated aqueous solubility and rapid activation by serum protein.
Another notable patent describes a cyclic chemical switching method for solubilizing and desolubilizing taxo-diterpenoids in aqueous solvents. This method employs 2-halogenated onium salts of aza-arenes to derivatize taxo-diterpenoids, altering their solubility. The process allows for a one-step derivatization that achieves solubilization, while desolubilization occurs through interaction with serum proteins, leading to the release of bioactive taxo-diterpenoids.
Career Highlights
Rodney K Guy is affiliated with The Scripps Research Institute, where he has been instrumental in advancing research in his field. His innovative approaches to drug solubility and delivery have garnered attention and recognition within the scientific community.
Collaborations
He has collaborated with notable scientists such as K C Nicolaou and Philippe G Nantermet, contributing to the advancement of research in nanotechnology and medicinal chemistry.
Conclusion
Rodney K Guy's work in the field of taxo-diterpenoid nanostruct