Company Filing History:
Years Active: 1998-2003
Title: Innovations of Rodney D. Gilchrist
Introduction
Rodney D. Gilchrist is a prominent inventor based in Oakville, Canada. He has made significant contributions to the field of genetics and biotechnology, holding a total of seven patents. His work focuses on improving the accuracy and efficiency of DNA sequencing processes.
Latest Patents
One of his latest patents is titled "Method and apparatus for alignment of signals for use in DNA base-calling." This invention involves aligning data traces from four channels of an automated electrophoresis detection apparatus by identifying peaks in each data trace. The method includes normalizing the data traces to achieve uniform peak heights and combining them for initial alignment. The coefficients of shift and stretch are determined by optimizing a cost function that reflects the overlap of peaks in the combined normalized data traces. This process results in four warped data traces that are aligned to form a cohesive data set, which can be displayed on a sequencing apparatus or used for base-calling.
Another significant patent is the "Method for sequencing nucleic acids with reduced errors." This method involves obtaining forward and reverse data sets for strands of a nucleic acid polymer. The apparent base sequences are compared to identify deviations from perfect complementarity. A confidence algorithm is applied to the peaks associated with these deviations to determine the correct base choice based on confidence values. This innovative approach enhances the accuracy of nucleic acid sequencing.
Career Highlights
Rodney D. Gilchrist has established himself as a key figure in the biotechnology industry through his work at Visible Genetics Inc. His inventions have paved the way for advancements in genetic research and diagnostics.
Collaborations
He has collaborated with notable colleagues, including Vrijmoed Chi and Ronald J. Green, contributing to a dynamic research environment that fosters innovation.
Conclusion
Rodney D. Gilchrist's contributions to the field of genetics through his patents and collaborative efforts highlight his role as a leading inventor. His work continues to influence advancements in DNA sequencing technology.
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