Company Filing History:
1 out of 3,540 
1 out of 1,217 
Years Active: 2000-2001
Title: Innovations in HIV-1 Research by Robert W Doms
Introduction
Robert W Doms is a notable inventor based in Berwyn, Pennsylvania, recognized for his contributions to the field of HIV research. He holds two patents that focus on immunogenic compositions and methods aimed at stimulating an immune response against the HIV-1 envelope protein. His work has significant implications for vaccine development and the fight against HIV.
Latest Patents
Doms' latest patents include innovative approaches to producing oligomeric HIV-1 envelope glycoproteins. One patent describes immunogenic compositions that feature a purified oligomeric structure comprising a C-terminally truncated form of the HIV-1 gp160 protein, which lacks the gp41 transmembrane domain. This composition retains the gp120-gp41 proteolytic processing site in one form while deleting it in another. The engineered envelope protein can be proteolytically cleaved, allowing the gp120 and gp41 components to remain noncovalently associated. Immunization with these compositions effectively stimulates the production of conformation-dependent antibodies. Another patent focuses on methods for producing recombinant HIV-1 envelope oligomers for use as immunogens. When gp140 oligomeric glycoproteins were purified and used to immunize mice, the resulting immune response favored the production of antibodies that recognize conformation-dependent epitopes on the HIV-1 envelope protein.
Career Highlights
Throughout his career, Robert W Doms has worked with prestigious organizations, including the National Institutes of Health, a component of the US Department of Health & Human Services, and the United States of America as represented by the Department of Health. His research has contributed significantly to the understanding and potential treatment of HIV.
Collaborations
Doms has collaborated with notable colleagues, including Patricia L Earl and Christopher C Broder, enhancing the impact of his research through shared expertise and insights.
Conclusion
Robert W Doms is a prominent figure in HIV research, with innovative patents that advance the development of effective immunogenic compositions. His work continues to play a crucial role in the ongoing battle against HIV infection.