Robert P Doyle

Title: Innovations by Robert P. Doyle

Introduction

Robert P. Doyle is an accomplished inventor based in Manlius, NY (US). He has made significant contributions to the field of biomedical research, particularly in the development of innovative treatments for obesity and macular degeneration. With a total of two patents to his name, Doyle's work showcases his commitment to advancing medical science.

Latest Patents

Doyle's latest patents include a monomeric peptide multi-agonist targeting the GLP1 receptor and NPY receptors. This series of chimeric peptides provides a mechanism for obesity treatment concomitant with Type 2 Diabetes Mellitus (T2DM) through dual agonism of the anorectic neuropeptide Y-receptor (Y2-R) and the glucoregulatory receptor GLP1-R. Preliminary results indicate that, depending on the selected peptide, once-daily administration can suppress food intake in male and female rats by 12-65% compared to baseline conditions before treatment. Additionally, glucose tolerance can be improved. The peptides also demonstrate Y1-receptor agonism, which offers protection to beta-islet cells against inflammatory damage. These peptides were designed to target serial anorectic pathways simultaneously, making them promising candidates for modulating food intake and glucoregulation in an effective and safe manner.

Another significant patent is an assay for detecting an A2E-Saposin B complex. This invention includes an assay and kit for detecting N-retinylidene-N-retinylethanolamine (A2E) in a sample. It utilizes a lipid binding protein, such as Saposin B, to capture A2E in the sample, assisting in the extraction and measurement of A2E via mass spectroscopy. A2E serves as a marker for macular degeneration, allowing the assay and kit to be used for detecting the presence or severity of this condition.

Career Highlights

Robert P. Doyle is affiliated with Syracuse University, where he continues to engage in groundbreaking research. His work has garnered attention for its potential impact on public health, particularly in addressing obesity and related metabolic disorders.

Collaborations

Doyle collaborates with Brandon Milliken, contributing to the advancement of their shared research goals. Their partnership exemplifies the importance of teamwork in scientific innovation.

Conclusion

Robert P. Doyle's contributions to the field of biomedical research through his innovative patents