Robert N Brey, Iii

Title: The Innovations of Robert N Brey, III

Introduction

Robert N Brey, III is a notable inventor based in Rochester, NY. He has made significant contributions to the field of biotechnology, particularly in the development of stable vectors for bacterial hosts. With a total of three patents to his name, Brey's work has implications for both fermentation processes and vaccine development.

Latest Patents

One of Brey's latest patents is titled "Stable purA vectors and uses therefor." This invention pertains to a complementation system for the selection and maintenance of expressed genes in bacterial hosts. The invention provides stable vectors that can be selected and maintained by complementation of chromosomal deletion mutations of purA (adenylosuccinate synthetase), obviating the use of antibiotic resistance genes. This system is particularly useful in production organisms during fermentation and in live vaccine bacteria, such as attenuated Salmonella typhi. It allows for the selection of chromosomal integrants and for stable plasmid maintenance in the vaccinated host without the application of external selection pressure.

Career Highlights

Throughout his career, Brey has worked with several prominent companies, including Praxis Biologics, Inc. and American Cyanamid Company. His experience in these organizations has contributed to his expertise in biotechnology and patent development.

Collaborations

Brey has collaborated with notable colleagues such as James P Fulginiti and Algis Anilionis. These collaborations have likely enriched his research and innovation efforts.

Conclusion

Robert N Brey, III is a distinguished inventor whose work in biotechnology has led to significant advancements in the field. His patents, particularly in the area of stable vectors, demonstrate his commitment to improving processes in fermentation and vaccine development.