Location History:
- Englewood Cliffs, NJ (US) (2012)
- Jamul, CA (US) (2013 - 2018)
Company Filing History:
Years Active: 2012-2018
Title: The Innovative Contributions of Robert Murphy
Introduction
Robert Murphy is an accomplished inventor based in Jamul, California. He holds a total of four patents, showcasing his expertise in the field of binding affinity scoring and ligand-receptor interactions. His innovative methods utilize computer analysis to enhance the understanding of molecular interactions, which is crucial in various scientific applications.
Latest Patents
One of Robert Murphy's latest patents focuses on binding affinity scoring with a penalty for breaking conjugation between aromatic ligand groups. This method employs computer analysis and databases to evaluate the energy changes that occur when a ligand molecule docks with a receptor molecule. It specifically accounts for the disruption of the π-conjugated character of the ligand, which is essential for accurate binding affinity predictions. Another significant patent addresses the scoring of binding affinity by penalizing compounds that create unfavorable hydrophobic contacts with localized water molecules in the receptor's active site. This method enhances the accuracy of ligand-receptor interaction predictions by considering the presence of localized water during docking.
Career Highlights
Throughout his career, Robert Murphy has worked with notable companies, including Schrödinger, LLC. His contributions to the field have been instrumental in advancing computational methods for drug discovery and molecular modeling. His innovative approaches have paved the way for more effective and efficient research in biochemistry and pharmacology.
Collaborations
Robert Murphy has collaborated with Richard A. Friesner, a prominent figure in the field of computational chemistry. Their partnership has led to significant advancements in understanding molecular interactions and improving computational techniques.
Conclusion
Robert Murphy's work exemplifies the intersection of innovation and technology in the realm of molecular science. His patents and career achievements highlight his commitment to enhancing our understanding of ligand-receptor interactions through advanced computational methods.