Robert Linhardt

Title: The Innovations of Robert Linhardt

Introduction

Robert Linhardt is a prominent inventor based in Iowa City, IA (US). He has made significant contributions to the field of biochemistry, particularly in the area of enzyme production. With a total of 2 patents, his work has advanced the understanding and application of chondroitin lyase enzymes.

Latest Patents

Linhardt's latest patents focus on the production of highly purified enzymes capable of degrading chondroitin sulfate polysaccharides. The first patent outlines a multi-step purification method that includes cell disruption, cation exchange chromatography, affinity chromatography, hydroxylapatite chromatography, high-resolution ion exchange chromatography, and size exclusion. This process has led to the isolation of a 77,000 ± 5,000 Dalton protein that can degrade chondroitin sulfates A and C, as well as a 55,000 ± 2,300 Dalton protein that degrades dermatan sulfate. Additionally, the genes encoding these enzymes, known as chondroitinase AC and chondroitinase B, have been cloned, and methods for their use are described in the patent.

Career Highlights

Robert Linhardt is currently associated with Ibex Technologies R and D, Inc., where he continues to innovate and contribute to the field. His work has not only advanced scientific knowledge but has also opened new avenues for research and application in biochemistry.

Collaborations

Linhardt has collaborated with notable colleagues, including D Clark Bennett and Maryse Laliberte, enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Robert Linhardt's contributions to the field of enzyme production and biochemistry are noteworthy. His innovative patents and collaborative efforts continue to influence the scientific community and pave the way for future advancements.