Company Filing History:
Years Active: 2019-2025
Title: The Innovative Contributions of Robert L. Abel
Introduction
Robert L. Abel is a notable inventor based in Brooklyn, NY, recognized for his significant contributions to the field of molecular simulations and drug discovery. With a total of 6 patents to his name, he has developed innovative methods that enhance the understanding of molecular systems and their transformations.
Latest Patents
Among his latest patents, Abel has introduced groundbreaking methods and systems for calculating free energy differences using a modified bond stretch potential. This method allows for the calculation of the free energy difference between a target state and a reference state by determining intermediate states through a coupling parameter. The process involves performing molecular simulations to obtain ensembles of micro-states for each system state, ultimately leading to a comprehensive analysis of these ensembles. This approach is particularly effective for calculating transformations in molecular systems, such as ring-opening and ring-closing, which involve bond breaking and formation.
Another significant patent focuses on predicting an active set of compounds with alternative cores, which is crucial for drug discovery. This system includes modules that identify the core of an initial lead compound and utilize computational techniques to calculate the relative binding free energy of potential lead compounds. The activity prediction module leverages these calculations to forecast an active set of compounds that can effectively bind to a biomolecular target, enhancing the drug discovery process.
Career Highlights
Robert L. Abel is currently employed at Schrödinger, Inc., where he continues to push the boundaries of innovation in molecular modeling and drug design. His work has not only advanced scientific understanding but has also contributed to practical applications in the pharmaceutical industry.
Collaborations
Throughout his career, Abel has collaborated with talented individuals such as Lingle Wang and Sayan Mondal, further enriching his research and development efforts.
Conclusion
Robert L. Abel's innovative work in molecular simulations and drug discovery exemplifies the impact of dedicated inventors in advancing science and technology. His contributions continue to shape the future of drug development and molecular research.
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