This inventor holds 2 USPTO granted patents and 1 published patent application, plus 1 CIPO patent. Top assignee: University System of Maryland. Active years: 2000.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2000
Title: Innovations in Cancer Research by Robert J Hickey
Introduction
Robert J Hickey is a notable inventor based in Abingdon, MD (US), recognized for his contributions to cancer research. He holds 2 patents that focus on innovative methods for detecting malignant cells and understanding DNA replication processes in breast cancer.
Latest Patents
Hickey's latest patents include a method for detecting the presence of malignant cells. This patent describes the isolation and purification of a multi-protein complex for DNA replication, known as the 'DNA synthesome', derived from MDA MB-468 human breast cancer cells and human breast tumor tissue. The DNA synthesome supports the in vitro replication of simian virus 40 (SV40) origin-containing DNA, indicating its role in both viral and human breast cell DNA replication. The study highlights the incorporation of various DNA proteins into the DNA synthesome, demonstrating its significance in mediating breast cell DNA replication.
Another patent focuses on an assay for measuring the activity and fidelity of DNA replication. This method utilizes the DNA synthesome to examine the cytotoxic effects of mercuric ions on DNA replication processes. The assay can rapidly screen compounds for toxic activity, providing valuable insights into the mechanisms of DNA replication and potential mutagenicity.
Career Highlights
Robert J Hickey is affiliated with the University System of Maryland, where he continues to advance research in the field of cancer biology. His work has significantly contributed to the understanding of DNA replication mechanisms in malignant cells, paving the way for potential therapeutic interventions.
Collaborations
Hickey has collaborated with notable colleagues, including Linda H Malkas and Jennifer W Sekowski, to further enhance the research and development of innovative cancer detection methods.
Conclusion
Robert J Hickey's innovative work in cancer research, particularly in the area of DNA replication and detection of malignant cells, showcases the importance of scientific advancements in understanding and combating cancer. His contributions continue to influence the field and offer hope for future breakthroughs.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile