Company Filing History:
Years Active: 2015
Title: The Innovative Contributions of Robert Gordon Miele
Introduction
Robert Gordon Miele is a notable inventor based in South Bend, Indiana. He has made significant contributions to the field of biotechnology, particularly in the engineering of mammalian-type carbohydrate structures. His work focuses on the production of therapeutic glycoproteins, which are essential in various medical applications.
Latest Patents
Miele holds a patent for a method to engineer mammalian-type carbohydrate structures. This invention relates to host cells that have modified lipid-linked oligosaccharides. These host cells can be further modified through the heterologous expression of glycosyltransferases, sugar transporters, and mannosidases. The engineered host cells are capable of expressing and targeting desirable genes involved in glycosylation. The N-glycans produced in these cells have a GlcNAcManGlcNAccore structure, which can be modified to yield human-like glycoproteins. This method is adaptable for the production of therapeutic proteins, allowing for the engineering of cell lines to achieve specific glycosylation structures.
Career Highlights
Miele is associated with Glycofi, Incorporated, where he applies his expertise in biotechnology. His work has been instrumental in advancing the production of therapeutic proteins, which are crucial for various medical treatments. His innovative approach to engineering host cells has opened new avenues in the field of glycoprotein production.
Collaborations
Miele has collaborated with notable colleagues such as Stefan Wildt and Juergen Nett. These collaborations have further enhanced the research and development of glycoprotein engineering, contributing to the advancement of biotechnological applications.
Conclusion
Robert Gordon Miele's contributions to the field of biotechnology, particularly in the engineering of carbohydrate structures, have significant implications for the production of therapeutic glycoproteins. His innovative methods and collaborations continue to influence advancements in medical biotechnology.
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